Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?

GÜL ŞİRAZ, ÜLKÜ; DOĞAN, MURAT; HATİPOĞLU, NİHAL; MUHTAROĞLU, SABAHATTİN; Kurtoglu, Selim

doi:10.4274/jcrpe.4532

Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?

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GÜL ŞİRAZ Ü., DOĞAN M., HATİPOĞLU N., MUHTAROĞLU S., Kurtoglu S.

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, vol.9, no.4, pp.293-299, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 9 Issue: 4
Publication Date: 2017
Doi Number: 10.4274/jcrpe.4532
Journal Name: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Page Numbers: pp.293-299
Galatasaray University Affiliated: No

Abstract

Objective: Metabolic impairment in type 1 diabetes mellitus (T1DM) with poor glycemic control causes insulin resistance, non-alcoholic fatty liver disease (NAFLD), atherosclerosis, and increased carotid intima-media thickness (CIMT). Fetuin-A has a protective effect in cardiovascular disorders and is increased in hepatosteatosis. We aimed to investigate the reliability of fetuin-A levels in early detection of diabetic complications in children with T1DM and to identify a cut-off value that may show poor metabolic control.